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These findings suggest that irisin alleviates MPTP-induced lactate metabolism in dopaminergic neurons, providing potential insights into its neuroprotective effects in PD

The metabolome results showed that 6 differential metabolites were enriched in galactose metabolism, 3 differential metabolites were enriched in fructose and mannose metabolism, and 1 differential metabolite was enriched in starch and sucrose metabolism

Many research teams have studied and prepared various biomaterials to address these issues and many cell delivery vehicles have been developed for the administration of MSCs and other therapeutic cells into the degenerated IVD (Table 2)

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